Nocturnal Enuresis is termed the involuntary loss of urine during the night sleep in adults, or in children older than 5 years. Nocturnal Enuresis is separated in two categories, Primary and Secondary. 

A. Primary Nocturnal Enuresis is caused by insufficient maturation of paraventricular cells of hypothalamus, resulting in defective nightly excretion of antidiuretic hormone, with psychological and heredity factors playing additional role. Treatment consists of use of alarm devices, antidiuretic hormone supplementation, anticholinergic medication, and psychological support of child and family.  

B. Secondary Nocturnal Enuresis, as its mane implies, is the result of neurological, psychiatry or endocrinologic disorder witch can be obvious or concealed.The treatment lies in the diagnosis and treatment of primary illness.